Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 849117..849774 Replicon chromosome
Accession NZ_CP113216
Organism Klebsiella pneumoniae strain SCLC9-2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OT489_RS04275 Protein ID WP_002916310.1
Coordinates 849364..849774 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OT489_RS04270 Protein ID WP_002916312.1
Coordinates 849117..849383 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT489_RS04245 (844273) 844273..845706 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
OT489_RS04250 (845825) 845825..846553 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OT489_RS04255 (846603) 846603..846914 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OT489_RS04260 (847078) 847078..847737 + 660 WP_002916317.1 hemolysin III family protein -
OT489_RS04265 (847888) 847888..848871 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OT489_RS04270 (849117) 849117..849383 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OT489_RS04275 (849364) 849364..849774 + 411 WP_002916310.1 protein YgfX Toxin
OT489_RS04280 (849781) 849781..850302 - 522 WP_002916308.1 flavodoxin FldB -
OT489_RS04285 (850403) 850403..851299 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OT489_RS04290 (851322) 851322..852035 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OT489_RS04295 (852041) 852041..853774 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T265610 WP_002916310.1 NZ_CP113216:849364-849774 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT265610 WP_002916312.1 NZ_CP113216:849117-849383 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References