26561

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 2219545..2220170 Replicon chromosome
Accession NC_017331
Organism Staphylococcus aureus subsp. aureus TW20

Toxin (Protein)


Gene name doc Uniprot ID A0A380FZ43
Locus tag SATW20_RS11430 Protein ID WP_001179607.1
Coordinates 2219545..2219940 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A380FXS4
Locus tag SATW20_RS11435 Protein ID WP_000258939.1
Coordinates 2219940..2220170 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SATW20_RS11390 2215100..2215540 - 441 Protein_2172 GNAT family N-acetyltransferase -
SATW20_RS11395 2215515..2215766 - 252 WP_002505594.1 hypothetical protein -
SATW20_RS11400 2215763..2216398 - 636 Protein_2174 aminoglycoside 6-adenylyltransferase -
SATW20_RS11405 2216613..2217335 - 723 WP_001043218.1 hypothetical protein -
SATW20_RS11410 2217444..2218244 - 801 WP_000686449.1 metallophosphoesterase -
SATW20_RS11415 2218248..2218742 - 495 WP_000280790.1 hypothetical protein -
SATW20_RS11420 2218799..2219068 - 270 WP_000755772.1 hypothetical protein -
SATW20_RS11425 2219052..2219243 - 192 WP_032605691.1 hypothetical protein -
SATW20_RS11430 2219545..2219940 - 396 WP_001179607.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
SATW20_RS11435 2219940..2220170 - 231 WP_000258939.1 addiction module antitoxin Antitoxin
SATW20_RS11445 2220346..2220867 - 522 WP_000639078.1 metallophosphoesterase -
SATW20_RS11450 2220867..2221517 - 651 WP_000411528.1 hypothetical protein -
SATW20_RS11455 2221517..2221834 - 318 WP_001807410.1 hypothetical protein -
SATW20_RS11460 2221827..2222552 - 726 WP_000197304.1 metallophosphoesterase -
SATW20_RS11465 2222552..2222773 - 222 WP_000829423.1 hypothetical protein -
SATW20_RS16980 2222793..2222969 - 177 WP_000063384.1 hypothetical protein -
SATW20_RS11470 2222962..2223504 - 543 WP_000858632.1 hypothetical protein -
SATW20_RS11475 2223519..2223791 - 273 WP_000691100.1 hypothetical protein -
SATW20_RS11480 2223817..2223972 - 156 WP_000792995.1 transcriptional regulator -
SATW20_RS16985 2224086..2224253 - 168 WP_000312832.1 hypothetical protein -
SATW20_RS11485 2224269..2224454 - 186 WP_001187008.1 hypothetical protein -
SATW20_RS11490 2224439..2224618 - 180 WP_000401832.1 hypothetical protein -
SATW20_RS11495 2224632..2225114 - 483 WP_000833764.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aac(6')-aph(2'') / aph(3')-III - 2181759..2312303 130544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15035.51 Da        Isoelectric Point: 9.4574

>T26561 WP_001179607.1 NC_017331:c2219940-2219545 [Staphylococcus aureus subsp. aureus TW20]
MQNIKYLTEKQVIAINVKAIQELSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFFNANKR
TAFTSMVIFLKLNKINFNCTQDEAVQFTLKVVEDKTLTLEDIADWIKRHCK

Download         Length: 396 bp

>T26561 NC_017331:c2219940-2219545 [Staphylococcus aureus subsp. aureus TW20]
ATGCAAAACATTAAATATTTAACTGAAAAACAAGTAATTGCCATTAATGTAAAAGCAATTCAAGAACTCTCACCTAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAGGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTTGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCGGCTTTTATATACAGAAATATAGCTCAAAAACATGCATTCTTTAATGCGAATAAGAGA
ACAGCTTTTACATCTATGGTTATTTTCTTGAAGTTAAATAAGATTAATTTTAATTGTACTCAAGACGAAGCGGTACAATT
TACTTTAAAAGTGGTAGAGGATAAAACTCTTACACTTGAAGATATTGCAGATTGGATCAAAAGGCATTGTAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8617.73 Da        Isoelectric Point: 4.4501

>AT26561 WP_000258939.1 NC_017331:c2220170-2219940 [Staphylococcus aureus subsp. aureus TW20]
MVTTRKLRRAGNSSVVSVPTEVIAALGVTNGDNLKFNIEDNKVTIEKEVNEDEEFFKLLDETFTEYNQALRKLVDI

Download         Length: 231 bp

>AT26561 NC_017331:c2220170-2219940 [Staphylococcus aureus subsp. aureus TW20]
ATGGTTACTACAAGAAAACTAAGAAGAGCTGGCAATAGTTCAGTTGTTTCTGTACCAACAGAAGTGATCGCAGCACTCGG
AGTTACAAATGGTGACAATCTTAAATTTAATATTGAAGATAATAAAGTAACCATTGAAAAGGAGGTAAACGAAGACGAAG
AGTTTTTCAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTCTGAGAAAGTTGGTTGACATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380FZ43

Antitoxin

Source ID Structure
AlphaFold DB A0A380FXS4

References