Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 54504..55240 Replicon plasmid pSYCC22-1_3
Accession NZ_CP113213
Organism Klebsiella pneumoniae strain SYCC22-1

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag OT491_RS27280 Protein ID WP_003026803.1
Coordinates 54758..55240 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag OT491_RS27275 Protein ID WP_003026799.1
Coordinates 54504..54770 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT491_RS27235 (OT491_27235) 49733..50095 - 363 WP_004152100.1 arsenite efflux transporter metallochaperone ArsD -
OT491_RS27240 (OT491_27240) 50145..50495 - 351 WP_004152101.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
OT491_RS27245 (OT491_27245) 50853..51101 + 249 WP_001568018.1 hypothetical protein -
OT491_RS27250 (OT491_27250) 51098..51670 + 573 WP_001568017.1 hypothetical protein -
OT491_RS27255 (OT491_27255) 51701..52195 + 495 WP_001568016.1 hypothetical protein -
OT491_RS27260 (OT491_27260) 52428..52778 - 351 WP_167878626.1 hypothetical protein -
OT491_RS27265 (OT491_27265) 53230..53778 + 549 WP_001567366.1 thioredoxin fold domain-containing protein -
OT491_RS27270 (OT491_27270) 53825..54259 + 435 WP_001567367.1 cell envelope integrity protein TolA -
OT491_RS27275 (OT491_27275) 54504..54770 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
OT491_RS27280 (OT491_27280) 54758..55240 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
OT491_RS27285 (OT491_27285) 55978..57222 + 1245 WP_124053351.1 hypothetical protein -
OT491_RS27290 (OT491_27290) 57215..57970 + 756 WP_100757158.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / aadA2 / blaTEM-1A / floR / aph(3')-Ia - 1..212905 212905


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T265604 WP_003026803.1 NZ_CP113213:54758-55240 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT265604 WP_003026799.1 NZ_CP113213:54504-54770 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References