Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 95251..96161 | Replicon | plasmid pSYCC22-1_2 |
| Accession | NZ_CP113212 | ||
| Organism | Klebsiella pneumoniae strain SYCC22-1 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | OT491_RS26160 | Protein ID | WP_004181896.1 |
| Coordinates | 95251..95721 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | OT491_RS26165 | Protein ID | WP_004181895.1 |
| Coordinates | 95718..96161 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OT491_RS26140 (OT491_26140) | 91322..92296 | - | 975 | WP_040222313.1 | hypothetical protein | - |
| OT491_RS26145 (OT491_26145) | 92899..93057 | - | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| OT491_RS26150 (OT491_26150) | 93129..94310 | + | 1182 | WP_004883380.1 | IS481 family transposase | - |
| OT491_RS26155 (OT491_26155) | 94881..95141 | + | 261 | WP_004026352.1 | hypothetical protein | - |
| OT491_RS26160 (OT491_26160) | 95251..95721 | - | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| OT491_RS26165 (OT491_26165) | 95718..96161 | - | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| OT491_RS26170 (OT491_26170) | 96262..97533 | - | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| OT491_RS26175 (OT491_26175) | 97533..97955 | - | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| OT491_RS26180 (OT491_26180) | 98041..99528 | - | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| OT491_RS26185 (OT491_26185) | 100220..100789 | - | 570 | Protein_93 | transposase | - |
| OT491_RS26190 (OT491_26190) | 100791..101006 | + | 216 | Protein_94 | IS200/IS605 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aph(6)-Id / aph(3'')-Ib / qnrB4 / blaDHA-1 / sul1 / armA / msr(E) / mph(E) | - | 1..249782 | 249782 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T265603 WP_004181896.1 NZ_CP113212:c95721-95251 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT265603 WP_004181895.1 NZ_CP113212:c96161-95718 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |