Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5176139..5176764 Replicon chromosome
Accession NZ_CP113211
Organism Klebsiella pneumoniae strain SYCC22-1

Toxin (Protein)


Gene name vapC Uniprot ID A0A378FVD4
Locus tag OT491_RS25355 Protein ID WP_019705794.1
Coordinates 5176139..5176522 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OT491_RS25360 Protein ID WP_004150355.1
Coordinates 5176522..5176764 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT491_RS25340 (5173505) 5173505..5174407 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OT491_RS25345 (5174404) 5174404..5175039 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OT491_RS25350 (5175036) 5175036..5175965 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OT491_RS25355 (5176139) 5176139..5176522 - 384 WP_019705794.1 type II toxin-antitoxin system VapC family toxin Toxin
OT491_RS25360 (5176522) 5176522..5176764 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OT491_RS25365 (5176969) 5176969..5177886 + 918 WP_004146235.1 alpha/beta hydrolase -
OT491_RS25370 (5177901) 5177901..5178842 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OT491_RS25375 (5178887) 5178887..5179324 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OT491_RS25380 (5179321) 5179321..5180181 - 861 WP_004146232.1 virulence factor BrkB family protein -
OT491_RS25385 (5180175) 5180175..5180774 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14358.57 Da        Isoelectric Point: 6.8806

>T265602 WP_019705794.1 NZ_CP113211:c5176522-5176139 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGHREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT265602 WP_004150355.1 NZ_CP113211:c5176764-5176522 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378FVD4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References