Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4833173..4834854 Replicon chromosome
Accession NZ_CP113211
Organism Klebsiella pneumoniae strain SYCC22-1

Toxin (Protein)


Gene name mosT Uniprot ID A0A483YLF8
Locus tag OT491_RS23790 Protein ID WP_019724882.1
Coordinates 4833173..4834090 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag OT491_RS23795 Protein ID WP_004177809.1
Coordinates 4834096..4834854 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT491_RS23770 (4828479) 4828479..4829999 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
OT491_RS23775 (4829996) 4829996..4830994 + 999 WP_002885172.1 ribose ABC transporter permease -
OT491_RS23780 (4831025) 4831025..4831966 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OT491_RS23785 (4832041) 4832041..4833048 + 1008 WP_064152101.1 carbohydrate kinase family protein -
OT491_RS23790 (4833173) 4833173..4834090 - 918 WP_019724882.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OT491_RS23795 (4834096) 4834096..4834854 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OT491_RS23800 (4834940) 4834940..4835668 - 729 WP_002885152.1 response regulator transcription factor -
OT491_RS23805 (4835941) 4835941..4838088 + 2148 WP_077625403.1 formate dehydrogenase subunit alpha -
OT491_RS23810 (4838318) 4838318..4839004 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34653.14 Da        Isoelectric Point: 5.4707

>T265601 WP_019724882.1 NZ_CP113211:c4834090-4833173 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT265601 WP_004177809.1 NZ_CP113211:c4834854-4834096 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YLF8

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References