Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4677696..4678212 Replicon chromosome
Accession NZ_CP113211
Organism Klebsiella pneumoniae strain SYCC22-1

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OT491_RS22985 Protein ID WP_004178374.1
Coordinates 4677696..4677980 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OT491_RS22990 Protein ID WP_002886901.1
Coordinates 4677970..4678212 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT491_RS22960 (4673091) 4673091..4673354 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
OT491_RS22965 (4673484) 4673484..4673657 + 174 WP_032412860.1 hypothetical protein -
OT491_RS22970 (4673660) 4673660..4674403 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OT491_RS22975 (4674760) 4674760..4676898 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OT491_RS22980 (4677228) 4677228..4677692 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OT491_RS22985 (4677696) 4677696..4677980 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT491_RS22990 (4677970) 4677970..4678212 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OT491_RS22995 (4678290) 4678290..4680200 - 1911 WP_004152270.1 PRD domain-containing protein -
OT491_RS23000 (4680223) 4680223..4681377 - 1155 WP_002886900.1 lactonase family protein -
OT491_RS23005 (4681444) 4681444..4682184 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T265600 WP_004178374.1 NZ_CP113211:c4677980-4677696 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT265600 WP_002886901.1 NZ_CP113211:c4678212-4677970 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References