Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 9186..9708 Replicon plasmid pSCLC4-1_5
Accession NZ_CP113206
Organism Klebsiella pneumoniae strain SCLC4-1

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag OT485_RS28670 Protein ID WP_000220561.1
Coordinates 9186..9467 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag OT485_RS28675 Protein ID WP_000121743.1
Coordinates 9457..9708 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT485_RS28640 (OT485_28645) 4365..5159 - 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
OT485_RS28645 (OT485_28650) 5188..6618 - 1431 Protein_5 IS4-like element IS50R family transposase -
OT485_RS28650 (OT485_28655) 6738..6926 + 189 WP_000957857.1 hypothetical protein -
OT485_RS28655 (OT485_28660) 6936..8135 + 1200 WP_000948429.1 IS91 family transposase -
OT485_RS28660 (OT485_28665) 8306..8689 + 384 Protein_8 transposase -
OT485_RS28665 (OT485_28670) 8855..8947 + 93 Protein_9 IS6 family transposase -
OT485_RS28670 (OT485_28675) 9186..9467 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT485_RS28675 (OT485_28680) 9457..9708 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
OT485_RS28680 (OT485_28685) 10943..11782 + 840 WP_024129959.1 replication initiation protein -
OT485_RS28685 (OT485_28690) 11803..12645 + 843 WP_063116919.1 replication initiation protein -
OT485_RS28690 (OT485_28695) 12649..13095 + 447 WP_001074384.1 hypothetical protein -
OT485_RS28695 (OT485_28700) 13232..13585 + 354 WP_024129958.1 DNA distortion polypeptide 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aph(3')-IIa - 1..36155 36155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T265590 WP_000220561.1 NZ_CP113206:c9467-9186 [Klebsiella pneumoniae]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT265590 WP_000121743.1 NZ_CP113206:c9708-9457 [Klebsiella pneumoniae]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References