Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 54500..55236 Replicon plasmid pSCLC4-1_3
Accession NZ_CP113204
Organism Klebsiella pneumoniae strain SCLC4-1

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag OT485_RS27490 Protein ID WP_003026803.1
Coordinates 54754..55236 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag OT485_RS27485 Protein ID WP_003026799.1
Coordinates 54500..54766 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT485_RS27445 (OT485_27450) 49729..50091 - 363 WP_004152100.1 arsenite efflux transporter metallochaperone ArsD -
OT485_RS27450 (OT485_27455) 50141..50491 - 351 WP_004152101.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
OT485_RS27455 (OT485_27460) 50849..51097 + 249 WP_001568018.1 hypothetical protein -
OT485_RS27460 (OT485_27465) 51094..51666 + 573 WP_001568017.1 hypothetical protein -
OT485_RS27465 (OT485_27470) 51697..52191 + 495 WP_001568016.1 hypothetical protein -
OT485_RS27470 (OT485_27475) 52424..52774 - 351 WP_167878626.1 hypothetical protein -
OT485_RS27475 (OT485_27480) 53226..53774 + 549 WP_001567366.1 thioredoxin fold domain-containing protein -
OT485_RS27480 (OT485_27485) 53821..54255 + 435 WP_001567367.1 cell envelope integrity protein TolA -
OT485_RS27485 (OT485_27490) 54500..54766 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
OT485_RS27490 (OT485_27495) 54754..55236 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
OT485_RS27495 (OT485_27500) 55974..57218 + 1245 WP_124053351.1 hypothetical protein -
OT485_RS27500 (OT485_27505) 57211..57966 + 756 WP_100757158.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / aadA2 / blaTEM-1A / floR / aph(3')-Ia - 1..211765 211765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T265588 WP_003026803.1 NZ_CP113204:54754-55236 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT265588 WP_003026799.1 NZ_CP113204:54500-54766 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References