Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4677705..4678221 Replicon chromosome
Accession NZ_CP113202
Organism Klebsiella pneumoniae strain SCLC4-1

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OT485_RS22985 Protein ID WP_004178374.1
Coordinates 4677705..4677989 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OT485_RS22990 Protein ID WP_002886901.1
Coordinates 4677979..4678221 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT485_RS22960 (4673100) 4673100..4673363 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
OT485_RS22965 (4673493) 4673493..4673666 + 174 WP_032412860.1 hypothetical protein -
OT485_RS22970 (4673669) 4673669..4674412 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OT485_RS22975 (4674769) 4674769..4676907 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OT485_RS22980 (4677237) 4677237..4677701 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OT485_RS22985 (4677705) 4677705..4677989 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT485_RS22990 (4677979) 4677979..4678221 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OT485_RS22995 (4678299) 4678299..4680209 - 1911 WP_004152270.1 PRD domain-containing protein -
OT485_RS23000 (4680232) 4680232..4681386 - 1155 WP_002886900.1 lactonase family protein -
OT485_RS23005 (4681453) 4681453..4682193 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T265584 WP_004178374.1 NZ_CP113202:c4677989-4677705 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT265584 WP_002886901.1 NZ_CP113202:c4678221-4677979 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References