Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2627589..2629177 Replicon chromosome
Accession NZ_CP113202
Organism Klebsiella pneumoniae strain SCLC4-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OT485_RS13035 Protein ID WP_064151580.1
Coordinates 2627589..2628911 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OT485_RS13040 Protein ID WP_004176198.1
Coordinates 2628911..2629177 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT485_RS13020 (2622645) 2622645..2625146 + 2502 WP_064151582.1 fimbria/pilus outer membrane usher protein -
OT485_RS13025 (2625134) 2625134..2626138 + 1005 WP_064151581.1 fimbrial protein -
OT485_RS13030 (2626280) 2626280..2627572 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OT485_RS13035 (2627589) 2627589..2628911 - 1323 WP_064151580.1 type II toxin-antitoxin system HipA family toxin Toxin
OT485_RS13040 (2628911) 2628911..2629177 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OT485_RS13045 (2629443) 2629443..2629769 - 327 WP_004176200.1 hydroxyisourate hydrolase -
OT485_RS13050 (2629766) 2629766..2630266 - 501 WP_064151579.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OT485_RS13055 (2630244) 2630244..2631623 - 1380 WP_065799905.1 nucleobase:cation symporter-2 family protein -
OT485_RS13060 (2631969) 2631969..2633123 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OT485_RS13065 (2633104) 2633104..2634027 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2434663..2662837 228174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T265581 WP_064151580.1 NZ_CP113202:c2628911-2627589 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
AHSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT265581 WP_004176198.1 NZ_CP113202:c2629177-2628911 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References