Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 799656..800313 Replicon chromosome
Accession NZ_CP113202
Organism Klebsiella pneumoniae strain SCLC4-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OT485_RS03965 Protein ID WP_002916310.1
Coordinates 799903..800313 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OT485_RS03960 Protein ID WP_002916312.1
Coordinates 799656..799922 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT485_RS03935 (794812) 794812..796245 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
OT485_RS03940 (796364) 796364..797092 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OT485_RS03945 (797142) 797142..797453 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OT485_RS03950 (797617) 797617..798276 + 660 WP_002916317.1 hemolysin III family protein -
OT485_RS03955 (798427) 798427..799410 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OT485_RS03960 (799656) 799656..799922 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OT485_RS03965 (799903) 799903..800313 + 411 WP_002916310.1 protein YgfX Toxin
OT485_RS03970 (800320) 800320..800841 - 522 WP_002916308.1 flavodoxin FldB -
OT485_RS03975 (800942) 800942..801838 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OT485_RS03980 (801861) 801861..802574 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OT485_RS03985 (802580) 802580..804313 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T265576 WP_002916310.1 NZ_CP113202:799903-800313 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT265576 WP_002916312.1 NZ_CP113202:799656-799922 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References