Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 40673..41583 | Replicon | plasmid pSCLC3-1_tmex_294k |
| Accession | NZ_CP113200 | ||
| Organism | Klebsiella pneumoniae strain SCLC3-1 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | OT487_RS26475 | Protein ID | WP_004181896.1 |
| Coordinates | 40673..41143 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | OT487_RS26480 | Protein ID | WP_004181895.1 |
| Coordinates | 41140..41583 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OT487_RS26455 (OT487_26450) | 36744..37718 | - | 975 | WP_040222313.1 | hypothetical protein | - |
| OT487_RS26460 (OT487_26455) | 38321..38479 | - | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| OT487_RS26465 (OT487_26460) | 38551..39732 | + | 1182 | WP_004883380.1 | IS481 family transposase | - |
| OT487_RS26470 (OT487_26465) | 40303..40563 | + | 261 | WP_004026352.1 | hypothetical protein | - |
| OT487_RS26475 (OT487_26470) | 40673..41143 | - | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| OT487_RS26480 (OT487_26475) | 41140..41583 | - | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| OT487_RS26485 (OT487_26480) | 41684..42955 | - | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| OT487_RS26490 (OT487_26485) | 42955..43377 | - | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| OT487_RS26495 (OT487_26490) | 43463..44950 | - | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| OT487_RS26500 (OT487_26495) | 45642..46211 | - | 570 | Protein_43 | transposase | - |
| OT487_RS26505 (OT487_26500) | 46213..46428 | + | 216 | Protein_44 | IS200/IS605 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aph(6)-Id / aph(3'')-Ib / qnrB4 / blaDHA-1 / sul1 / armA / msr(E) / mph(E) / aph(3')-Ia / aph(4)-Ia / aac(3)-IVa / sul3 / ant(3'')-Ia / cmlA1 / aadA2 | - | 1..294073 | 294073 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T265573 WP_004181896.1 NZ_CP113200:c41143-40673 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT265573 WP_004181895.1 NZ_CP113200:c41583-41140 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |