Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5177873..5178498 Replicon chromosome
Accession NZ_CP113197
Organism Klebsiella pneumoniae strain SCLC3-1

Toxin (Protein)


Gene name vapC Uniprot ID A0A378FVD4
Locus tag OT487_RS25375 Protein ID WP_019705794.1
Coordinates 5177873..5178256 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OT487_RS25380 Protein ID WP_004150355.1
Coordinates 5178256..5178498 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT487_RS25360 (5175239) 5175239..5176141 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OT487_RS25365 (5176138) 5176138..5176773 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OT487_RS25370 (5176770) 5176770..5177699 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OT487_RS25375 (5177873) 5177873..5178256 - 384 WP_019705794.1 type II toxin-antitoxin system VapC family toxin Toxin
OT487_RS25380 (5178256) 5178256..5178498 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OT487_RS25385 (5178703) 5178703..5179620 + 918 WP_004146235.1 alpha/beta hydrolase -
OT487_RS25390 (5179635) 5179635..5180576 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OT487_RS25395 (5180621) 5180621..5181058 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OT487_RS25400 (5181055) 5181055..5181915 - 861 WP_004146232.1 virulence factor BrkB family protein -
OT487_RS25405 (5181909) 5181909..5182508 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14358.57 Da        Isoelectric Point: 6.8806

>T265570 WP_019705794.1 NZ_CP113197:c5178256-5177873 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGHREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT265570 WP_004150355.1 NZ_CP113197:c5178498-5178256 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378FVD4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References