Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4834907..4836588 Replicon chromosome
Accession NZ_CP113197
Organism Klebsiella pneumoniae strain SCLC3-1

Toxin (Protein)


Gene name mosT Uniprot ID A0A483YLF8
Locus tag OT487_RS23810 Protein ID WP_019724882.1
Coordinates 4834907..4835824 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag OT487_RS23815 Protein ID WP_004177809.1
Coordinates 4835830..4836588 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT487_RS23790 (4830213) 4830213..4831733 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
OT487_RS23795 (4831730) 4831730..4832728 + 999 WP_002885172.1 ribose ABC transporter permease -
OT487_RS23800 (4832759) 4832759..4833700 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OT487_RS23805 (4833775) 4833775..4834782 + 1008 WP_064152101.1 carbohydrate kinase family protein -
OT487_RS23810 (4834907) 4834907..4835824 - 918 WP_019724882.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OT487_RS23815 (4835830) 4835830..4836588 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OT487_RS23820 (4836674) 4836674..4837402 - 729 WP_002885152.1 response regulator transcription factor -
OT487_RS23825 (4837675) 4837675..4839822 + 2148 WP_077625403.1 formate dehydrogenase subunit alpha -
OT487_RS23830 (4840052) 4840052..4840738 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34653.14 Da        Isoelectric Point: 5.4707

>T265569 WP_019724882.1 NZ_CP113197:c4835824-4834907 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT265569 WP_004177809.1 NZ_CP113197:c4836588-4835830 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YLF8

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References