Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4679430..4679946 Replicon chromosome
Accession NZ_CP113197
Organism Klebsiella pneumoniae strain SCLC3-1

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OT487_RS23005 Protein ID WP_004178374.1
Coordinates 4679430..4679714 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OT487_RS23010 Protein ID WP_002886901.1
Coordinates 4679704..4679946 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT487_RS22980 (4674825) 4674825..4675088 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
OT487_RS22985 (4675218) 4675218..4675391 + 174 WP_032412860.1 hypothetical protein -
OT487_RS22990 (4675394) 4675394..4676137 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OT487_RS22995 (4676494) 4676494..4678632 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OT487_RS23000 (4678962) 4678962..4679426 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OT487_RS23005 (4679430) 4679430..4679714 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT487_RS23010 (4679704) 4679704..4679946 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OT487_RS23015 (4680024) 4680024..4681934 - 1911 WP_004152270.1 PRD domain-containing protein -
OT487_RS23020 (4681957) 4681957..4683111 - 1155 WP_002886900.1 lactonase family protein -
OT487_RS23025 (4683178) 4683178..4683918 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T265568 WP_004178374.1 NZ_CP113197:c4679714-4679430 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT265568 WP_002886901.1 NZ_CP113197:c4679946-4679704 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References