265558

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 273237..273759 Replicon plasmid pSXC4-2_tmex_350k
Accession NZ_CP113193
Organism Klebsiella pneumoniae strain SXC4-2

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag OT483_RS27085 Protein ID WP_004181778.1
Coordinates 273475..273759 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag OT483_RS27080 Protein ID WP_025368601.1
Coordinates 273237..273485 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT483_RS27060 (OT483_27060) 268437..269273 - 837 WP_227520814.1 hypothetical protein -
OT483_RS27065 (OT483_27065) 269320..269673 - 354 WP_004181774.1 hypothetical protein -
OT483_RS27070 (OT483_27070) 269818..270813 - 996 WP_046654939.1 hypothetical protein -
OT483_RS27075 (OT483_27075) 271147..272946 - 1800 WP_042935572.1 ATP-dependent helicase -
OT483_RS27080 (OT483_27080) 273237..273485 + 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OT483_RS27085 (OT483_27085) 273475..273759 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT483_RS27090 (OT483_27090) 273989..275215 + 1227 WP_042935575.1 RNA-guided endonuclease TnpB family protein -
OT483_RS27095 (OT483_27095) 275501..275926 - 426 WP_040120489.1 IS200/IS605 family transposase -
OT483_RS27100 (OT483_27100) 275963..277189 + 1227 WP_025368604.1 RNA-guided endonuclease TnpB family protein -
OT483_RS27105 (OT483_27105) 277255..278381 - 1127 Protein_307 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / qacE / dfrA12 / aph(3')-IIa / mph(A) / fosA3 / sul2 / tet(A) / floR / blaTEM-1B / rmtB / blaDHA-1 / qnrB4 - 1..350595 350595


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T265558 WP_004181778.1 NZ_CP113193:273475-273759 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT265558 WP_025368601.1 NZ_CP113193:273237-273485 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References