Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 33439..34349 | Replicon | plasmid pSXC4-2_tmex_350k |
| Accession | NZ_CP113193 | ||
| Organism | Klebsiella pneumoniae strain SXC4-2 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | OT483_RS25790 | Protein ID | WP_004026354.1 |
| Coordinates | 33879..34349 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | OT483_RS25785 | Protein ID | WP_004026357.1 |
| Coordinates | 33439..33882 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OT483_RS25770 (OT483_25770) | 29749..31236 | - | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| OT483_RS25775 (OT483_25775) | 31645..32067 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| OT483_RS25780 (OT483_25780) | 32067..33338 | + | 1272 | WP_201621187.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| OT483_RS25785 (OT483_25785) | 33439..33882 | + | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| OT483_RS25790 (OT483_25790) | 33879..34349 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| OT483_RS25795 (OT483_25795) | 34804..34992 | - | 189 | WP_024198076.1 | hypothetical protein | - |
| OT483_RS25800 (OT483_25800) | 35604..35864 | - | 261 | WP_201621188.1 | hypothetical protein | - |
| OT483_RS25805 (OT483_25805) | 36587..36745 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| OT483_RS25810 (OT483_25810) | 37350..38324 | + | 975 | WP_032719543.1 | hypothetical protein | - |
| OT483_RS25815 (OT483_25815) | 38521..38898 | - | 378 | WP_032719541.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / qacE / dfrA12 / aph(3')-IIa / mph(A) / fosA3 / sul2 / tet(A) / floR / blaTEM-1B / rmtB / blaDHA-1 / qnrB4 | - | 1..350595 | 350595 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T265555 WP_004026354.1 NZ_CP113193:33879-34349 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT265555 WP_004026357.1 NZ_CP113193:33439-33882 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |