Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 33439..34349 Replicon plasmid pSXC4-2_tmex_350k
Accession NZ_CP113193
Organism Klebsiella pneumoniae strain SXC4-2

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag OT483_RS25790 Protein ID WP_004026354.1
Coordinates 33879..34349 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag OT483_RS25785 Protein ID WP_004026357.1
Coordinates 33439..33882 (+) Length 148 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT483_RS25770 (OT483_25770) 29749..31236 - 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
OT483_RS25775 (OT483_25775) 31645..32067 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
OT483_RS25780 (OT483_25780) 32067..33338 + 1272 WP_201621187.1 translesion error-prone DNA polymerase V subunit UmuC -
OT483_RS25785 (OT483_25785) 33439..33882 + 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
OT483_RS25790 (OT483_25790) 33879..34349 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
OT483_RS25795 (OT483_25795) 34804..34992 - 189 WP_024198076.1 hypothetical protein -
OT483_RS25800 (OT483_25800) 35604..35864 - 261 WP_201621188.1 hypothetical protein -
OT483_RS25805 (OT483_25805) 36587..36745 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
OT483_RS25810 (OT483_25810) 37350..38324 + 975 WP_032719543.1 hypothetical protein -
OT483_RS25815 (OT483_25815) 38521..38898 - 378 WP_032719541.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / qacE / dfrA12 / aph(3')-IIa / mph(A) / fosA3 / sul2 / tet(A) / floR / blaTEM-1B / rmtB / blaDHA-1 / qnrB4 - 1..350595 350595


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-148)

Antitoxin

(30-89)


Sequences


Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T265555 WP_004026354.1 NZ_CP113193:33879-34349 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp


Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT265555 WP_004026357.1 NZ_CP113193:33439-33882 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A663AYG0


Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References