Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 5148734..5149359 | Replicon | chromosome |
Accession | NZ_CP113192 | ||
Organism | Klebsiella pneumoniae strain SXC4-2 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | R4Y4A3 |
Locus tag | OT483_RS25205 | Protein ID | WP_002882817.1 |
Coordinates | 5148734..5149117 (-) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | J2DFR0 |
Locus tag | OT483_RS25210 | Protein ID | WP_004150355.1 |
Coordinates | 5149117..5149359 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OT483_RS25190 (5146100) | 5146100..5147002 | + | 903 | WP_002882822.1 | formate dehydrogenase subunit beta | - |
OT483_RS25195 (5146999) | 5146999..5147634 | + | 636 | WP_002882818.1 | formate dehydrogenase cytochrome b556 subunit | - |
OT483_RS25200 (5147631) | 5147631..5148560 | + | 930 | WP_004150358.1 | formate dehydrogenase accessory protein FdhE | - |
OT483_RS25205 (5148734) | 5148734..5149117 | - | 384 | WP_002882817.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
OT483_RS25210 (5149117) | 5149117..5149359 | - | 243 | WP_004150355.1 | CopG family transcriptional regulator | Antitoxin |
OT483_RS25215 (5149564) | 5149564..5150481 | + | 918 | WP_004178029.1 | alpha/beta hydrolase | - |
OT483_RS25220 (5150495) | 5150495..5151436 | - | 942 | WP_004178031.1 | fatty acid biosynthesis protein FabY | - |
OT483_RS25225 (5151481) | 5151481..5151918 | - | 438 | WP_002882809.1 | D-aminoacyl-tRNA deacylase | - |
OT483_RS25230 (5151915) | 5151915..5152775 | - | 861 | WP_004146232.1 | virulence factor BrkB family protein | - |
OT483_RS25235 (5152769) | 5152769..5153368 | - | 600 | WP_004151865.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14377.62 Da Isoelectric Point: 7.3178
>T265554 WP_002882817.1 NZ_CP113192:c5149117-5148734 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
Download Length: 384 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GPK8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GGU9 |