265553

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4829052..4830733 Replicon chromosome
Accession NZ_CP113192
Organism Klebsiella pneumoniae strain SXC4-2

Toxin (Protein)


Gene name mosT Uniprot ID A6TH06
Locus tag OT483_RS23725 Protein ID WP_015959269.1
Coordinates 4829052..4829927 (-) Length 292 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag OT483_RS23730 Protein ID WP_004177809.1
Coordinates 4829975..4830733 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT483_RS23705 (4824358) 4824358..4825878 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
OT483_RS23710 (4825875) 4825875..4826873 + 999 WP_002885172.1 ribose ABC transporter permease -
OT483_RS23715 (4826904) 4826904..4827845 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OT483_RS23720 (4827920) 4827920..4828927 + 1008 WP_004177805.1 carbohydrate kinase family protein -
OT483_RS23725 (4829052) 4829052..4829927 - 876 WP_015959269.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OT483_RS23730 (4829975) 4829975..4830733 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OT483_RS23735 (4830819) 4830819..4831547 - 729 WP_002885152.1 response regulator transcription factor -
OT483_RS23740 (4831820) 4831820..4833967 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
OT483_RS23745 (4833964) 4833964..4834107 - 144 WP_164523424.1 hypothetical protein -
OT483_RS23750 (4834242) 4834242..4835605 + 1364 WP_085955203.1 IS3-like element ISKpn1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(7-264)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 292 a.a.        Molecular weight: 32990.17 Da        Isoelectric Point: 5.4637

>T265553 WP_015959269.1 NZ_CP113192:c4829927-4829052 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 876 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT265553 WP_004177809.1 NZ_CP113192:c4830733-4829975 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6TH06

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References