265552

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4669141..4669657 Replicon chromosome
Accession NZ_CP113192
Organism Klebsiella pneumoniae strain SXC4-2

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag OT483_RS22905 Protein ID WP_009309309.1
Coordinates 4669141..4669425 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OT483_RS22910 Protein ID WP_002886901.1
Coordinates 4669415..4669657 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT483_RS22880 (4664537) 4664537..4664800 - 264 WP_025368518.1 PTS sugar transporter subunit IIB -
OT483_RS22885 (4664930) 4664930..4665103 + 174 WP_002886906.1 hypothetical protein -
OT483_RS22890 (4665106) 4665106..4665849 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OT483_RS22895 (4666206) 4666206..4668344 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OT483_RS22900 (4668673) 4668673..4669137 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OT483_RS22905 (4669141) 4669141..4669425 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT483_RS22910 (4669415) 4669415..4669657 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OT483_RS22915 (4669735) 4669735..4671645 - 1911 WP_004152270.1 PRD domain-containing protein -
OT483_RS22920 (4671668) 4671668..4672822 - 1155 WP_023159544.1 lactonase family protein -
OT483_RS22925 (4672889) 4672889..4673629 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T265552 WP_009309309.1 NZ_CP113192:c4669425-4669141 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT265552 WP_002886901.1 NZ_CP113192:c4669657-4669415 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References