Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2714232..2715820 | Replicon | chromosome |
Accession | NZ_CP113192 | ||
Organism | Klebsiella pneumoniae strain SXC4-2 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A486BIX7 |
Locus tag | OT483_RS13535 | Protein ID | WP_040151071.1 |
Coordinates | 2714232..2715554 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | OT483_RS13540 | Protein ID | WP_004176198.1 |
Coordinates | 2715554..2715820 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OT483_RS13520 (2709288) | 2709288..2711789 | + | 2502 | WP_101999384.1 | fimbria/pilus outer membrane usher protein | - |
OT483_RS13525 (2711777) | 2711777..2712781 | + | 1005 | WP_009308876.1 | fimbrial protein | - |
OT483_RS13530 (2712923) | 2712923..2714215 | + | 1293 | WP_015958402.1 | glycoside hydrolase family 10 protein | - |
OT483_RS13535 (2714232) | 2714232..2715554 | - | 1323 | WP_040151071.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
OT483_RS13540 (2715554) | 2715554..2715820 | - | 267 | WP_004176198.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
OT483_RS13545 (2716206) | 2716206..2716532 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
OT483_RS13550 (2716529) | 2716529..2717029 | - | 501 | WP_002904787.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
OT483_RS13555 (2717007) | 2717007..2718386 | - | 1380 | WP_080787014.1 | nucleobase:cation symporter-2 family protein | - |
OT483_RS13560 (2718732) | 2718732..2719886 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
OT483_RS13565 (2719867) | 2719867..2720790 | - | 924 | WP_048980813.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49199.47 Da Isoelectric Point: 7.2488
>T265549 WP_040151071.1 NZ_CP113192:c2715554-2714232 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPDIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPDIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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