Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2714232..2715820 Replicon chromosome
Accession NZ_CP113192
Organism Klebsiella pneumoniae strain SXC4-2

Toxin (Protein)


Gene name hipA Uniprot ID A0A486BIX7
Locus tag OT483_RS13535 Protein ID WP_040151071.1
Coordinates 2714232..2715554 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OT483_RS13540 Protein ID WP_004176198.1
Coordinates 2715554..2715820 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT483_RS13520 (2709288) 2709288..2711789 + 2502 WP_101999384.1 fimbria/pilus outer membrane usher protein -
OT483_RS13525 (2711777) 2711777..2712781 + 1005 WP_009308876.1 fimbrial protein -
OT483_RS13530 (2712923) 2712923..2714215 + 1293 WP_015958402.1 glycoside hydrolase family 10 protein -
OT483_RS13535 (2714232) 2714232..2715554 - 1323 WP_040151071.1 type II toxin-antitoxin system HipA family toxin Toxin
OT483_RS13540 (2715554) 2715554..2715820 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OT483_RS13545 (2716206) 2716206..2716532 - 327 WP_002904788.1 hydroxyisourate hydrolase -
OT483_RS13550 (2716529) 2716529..2717029 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OT483_RS13555 (2717007) 2717007..2718386 - 1380 WP_080787014.1 nucleobase:cation symporter-2 family protein -
OT483_RS13560 (2718732) 2718732..2719886 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OT483_RS13565 (2719867) 2719867..2720790 - 924 WP_048980813.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49199.47 Da        Isoelectric Point: 7.2488

>T265549 WP_040151071.1 NZ_CP113192:c2715554-2714232 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPDIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT265549 WP_004176198.1 NZ_CP113192:c2715820-2715554 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486BIX7

Antitoxin

Source ID Structure

References