Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4475146..4475825 Replicon chromosome
Accession NZ_CP113191
Organism Klebsiella pneumoniae strain SYCC2

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag OT482_RS24760 Protein ID WP_020324801.1
Coordinates 4475146..4475487 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag OT482_RS24765 Protein ID WP_020324792.1
Coordinates 4475508..4475825 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT482_RS24740 (4471447) 4471447..4473288 + 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -
OT482_RS24745 (4473388) 4473388..4473894 - 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
OT482_RS24755 (4474197) 4474197..4475030 - 834 WP_020324805.1 DUF4942 domain-containing protein -
OT482_RS24760 (4475146) 4475146..4475487 - 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
OT482_RS24765 (4475508) 4475508..4475825 - 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OT482_RS24770 (4475838) 4475838..4476065 - 228 WP_020324796.1 DUF987 domain-containing protein -
OT482_RS24775 (4476074) 4476074..4476550 - 477 WP_020324797.1 RadC family protein -
OT482_RS24780 (4476566) 4476566..4477024 - 459 WP_020324813.1 antirestriction protein -
OT482_RS24785 (4477127) 4477127..4477366 - 240 WP_020324820.1 DUF905 domain-containing protein -
OT482_RS24790 (4477459) 4477459..4480611 - 3153 WP_022631414.1 AIDA repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimG / fimF / fimD / fimD / fimC / fimI / fimA 4475146..4522612 47466


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T265538 WP_020324801.1 NZ_CP113191:c4475487-4475146 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT265538 WP_020324792.1 NZ_CP113191:c4475825-4475508 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References