Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4328531..4329188 Replicon chromosome
Accession NZ_CP113191
Organism Klebsiella pneumoniae strain SYCC2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OT482_RS24010 Protein ID WP_002916310.1
Coordinates 4328531..4328941 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OT482_RS24015 Protein ID WP_002916312.1
Coordinates 4328922..4329188 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT482_RS23990 (4324531) 4324531..4326264 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
OT482_RS23995 (4326270) 4326270..4326983 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OT482_RS24000 (4327006) 4327006..4327902 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OT482_RS24005 (4328003) 4328003..4328524 + 522 WP_004144730.1 flavodoxin FldB -
OT482_RS24010 (4328531) 4328531..4328941 - 411 WP_002916310.1 protein YgfX Toxin
OT482_RS24015 (4328922) 4328922..4329188 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OT482_RS24020 (4329434) 4329434..4330417 + 984 WP_020324927.1 tRNA-modifying protein YgfZ -
OT482_RS24025 (4330568) 4330568..4331227 - 660 WP_002916317.1 hemolysin III family protein -
OT482_RS24030 (4331391) 4331391..4331702 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
OT482_RS24035 (4331752) 4331752..4332480 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OT482_RS24040 (4332599) 4332599..4334032 + 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T265537 WP_002916310.1 NZ_CP113191:c4328941-4328531 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT265537 WP_002916312.1 NZ_CP113191:c4329188-4328922 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References