Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2508287..2509875 Replicon chromosome
Accession NZ_CP113191
Organism Klebsiella pneumoniae strain SYCC2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OT482_RS15080 Protein ID WP_004179815.1
Coordinates 2508553..2509875 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OT482_RS15075 Protein ID WP_004176198.1
Coordinates 2508287..2508553 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT482_RS15050 (2503437) 2503437..2504360 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
OT482_RS15055 (2504341) 2504341..2505495 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OT482_RS15060 (2505841) 2505841..2507220 + 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
OT482_RS15065 (2507198) 2507198..2507698 + 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OT482_RS15070 (2507695) 2507695..2508021 + 327 WP_002904788.1 hydroxyisourate hydrolase -
OT482_RS15075 (2508287) 2508287..2508553 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OT482_RS15080 (2508553) 2508553..2509875 + 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
OT482_RS15085 (2509892) 2509892..2511184 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OT482_RS15090 (2511326) 2511326..2512330 - 1005 WP_004179822.1 fimbrial protein -
OT482_RS15095 (2512318) 2512318..2514819 - 2502 WP_267690060.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T265532 WP_004179815.1 NZ_CP113191:2508553-2509875 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT265532 WP_004176198.1 NZ_CP113191:2508287-2508553 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References