Detailed information of TA system TA026553

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 956755..957260
• Replicon: chromosome
• Accession: NC_017331
• Organism: Staphylococcus aureus subsp. aureus TW20

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A0C6E6D5
• Locus tag: SATW20_RS04815
• Protein ID: WP_001103946.1
• Coordinates: 956967..957260 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IA75
• Locus tag: SATW20_RS04810
• Protein ID: WP_001058492.1
• Coordinates: 956755..956964 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SATW20_RS04775	952272..953492	-	1221	WP_000264182.1	site-specific integrase	-
SATW20_RS04780	953580..954308	-	729	WP_000733773.1	staphylococcal enterotoxin type K	-
SATW20_RS04785	954332..955060	-	729	WP_001033317.1	staphylococcal enterotoxin type Q	-
SATW20_RS04790	955235..955969	-	735	WP_000142630.1	helix-turn-helix domain-containing protein	-
SATW20_RS04795	956119..956331	+	213	WP_001063624.1	helix-turn-helix transcriptional regulator	-
SATW20_RS04800	956332..956604	+	273	WP_001138298.1	helix-turn-helix domain-containing protein	-
SATW20_RS04805	956616..956762	+	147	WP_000784885.1	hypothetical protein	-
SATW20_RS04810	956755..956964	+	210	WP_001058492.1	hypothetical protein	Antitoxin
SATW20_RS04815	956967..957260	+	294	WP_001103946.1	DUF1474 family protein	Toxin
SATW20_RS04820	957348..958217	+	870	WP_001002691.1	primase alpha helix C-terminal domain-containing protein	-
SATW20_RS04825	958234..959691	+	1458	WP_000432707.1	virulence-associated E family protein	-
SATW20_RS04830	959993..960355	+	363	WP_001039172.1	hypothetical protein	-
SATW20_RS04835	960357..960641	+	285	WP_000998180.1	hypothetical protein	-
SATW20_RS04840	960638..961279	+	642	WP_001019783.1	hypothetical protein	-
SATW20_RS04845	961728..962069	+	342	WP_001190616.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq	934321..964383	30062

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-97)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11590.08 Da
• Isoelectric Point: 4.9594

>T26553 WP_001103946.1 NC_017331:956967-957260 [Staphylococcus aureus subsp. aureus TW20]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA

Nucleotide

• Length: 294 bp

>T26553 NC_017331:956967-957260 [Staphylococcus aureus subsp. aureus TW20]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGATCAAAGCGAAAGTAACGCATAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.28 Da
• Isoelectric Point: 4.3718

>AT26553 WP_001058492.1 NC_017331:956755-956964 [Staphylococcus aureus subsp. aureus TW20]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT26553 NC_017331:956755-956964 [Staphylococcus aureus subsp. aureus TW20]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: A0A0C6E6D5

Antitoxin

• AlphaFold DB: X5IA75