Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 396780..397296 Replicon chromosome
Accession NZ_CP113191
Organism Klebsiella pneumoniae strain SYCC2

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OT482_RS04865 Protein ID WP_004178374.1
Coordinates 397012..397296 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OT482_RS04860 Protein ID WP_002886901.1
Coordinates 396780..397022 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT482_RS04845 (392808) 392808..393548 + 741 WP_002886899.1 KDGP aldolase family protein -
OT482_RS04850 (393615) 393615..394769 + 1155 WP_004178372.1 lactonase family protein -
OT482_RS04855 (394792) 394792..396702 + 1911 WP_004178373.1 PRD domain-containing protein -
OT482_RS04860 (396780) 396780..397022 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OT482_RS04865 (397012) 397012..397296 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT482_RS04870 (397300) 397300..397764 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OT482_RS04875 (398005) 398005..400143 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OT482_RS04880 (400500) 400500..401243 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OT482_RS04885 (401246) 401246..401419 - 174 WP_032408826.1 hypothetical protein -
OT482_RS04890 (401504) 401504..401812 + 309 WP_022631369.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T265528 WP_004178374.1 NZ_CP113191:397012-397296 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT265528 WP_002886901.1 NZ_CP113191:396780-397022 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References