Detailed information of TA system TA265527

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 239919..241600
• Replicon: chromosome
• Accession: NZ_CP113191
• Organism: Klebsiella pneumoniae strain SYCC2

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: OT482_RS04075
• Protein ID: WP_004178299.1
• Coordinates: 240683..241600 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: OT482_RS04070
• Protein ID: WP_004177809.1
• Coordinates: 239919..240677 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OT482_RS04050 (235421)	235421..236107	-	687	WP_004151733.1	tetratricopeptide repeat protein	-
OT482_RS04055 (236545)	236545..236688	+	144	WP_022631365.1	hypothetical protein	-
OT482_RS04060 (236685)	236685..238832	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
OT482_RS04065 (239105)	239105..239833	+	729	WP_004178298.1	response regulator transcription factor	-
OT482_RS04070 (239919)	239919..240677	+	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
OT482_RS04075 (240683)	240683..241600	+	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
OT482_RS04080 (241725)	241725..242732	-	1008	WP_004178300.1	carbohydrate kinase family protein	-
OT482_RS04085 (242807)	242807..243748	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
OT482_RS04090 (243779)	243779..244777	-	999	WP_002885172.1	ribose ABC transporter permease	-
OT482_RS04095 (244774)	244774..246294	-	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T265527 WP_004178299.1 NZ_CP113191:240683-241600 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT265527 WP_004177809.1 NZ_CP113191:239919-240677 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05