265526

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 5867..6392 Replicon plasmid pSYCC2_5
Accession NZ_CP113189
Organism Klebsiella pneumoniae strain SYCC2

Toxin (Protein)


Gene name ccdB Uniprot ID D4HQE7
Locus tag OT482_RS02575 Protein ID WP_013023785.1
Coordinates 5867..6172 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag OT482_RS02580 Protein ID WP_001568025.1
Coordinates 6174..6392 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT482_RS02545 (OT482_02545) 1567..2193 + 627 WP_004197649.1 ParA family plasmid-partitioning AAA ATPase -
OT482_RS02550 (OT482_02550) 2190..2492 + 303 WP_004197636.1 hypothetical protein -
OT482_RS02555 (OT482_02555) 2948..3742 - 795 WP_004197635.1 site-specific integrase -
OT482_RS02560 (OT482_02560) 3940..4956 - 1017 WP_267689862.1 hypothetical protein -
OT482_RS02565 (OT482_02565) 4953..5276 - 324 WP_004197641.1 hypothetical protein -
OT482_RS02570 (OT482_02570) 5303..5698 - 396 WP_017899885.1 hypothetical protein -
OT482_RS02575 (OT482_02575) 5867..6172 - 306 WP_013023785.1 type II toxin-antitoxin system toxin CcdB Toxin
OT482_RS02580 (OT482_02580) 6174..6392 - 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
OT482_RS02585 (OT482_02590) 7210..7500 - 291 WP_013023783.1 hypothetical protein -
OT482_RS02590 (OT482_02595) 7497..8624 - 1128 WP_013023782.1 DUF4238 domain-containing protein -
OT482_RS02595 (OT482_02600) 8658..10181 - 1524 WP_017899887.1 hypothetical protein -
OT482_RS02600 (OT482_02605) 10457..11236 - 780 WP_013023780.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid floR / tet(A) / mph(A) / sul1 / qnrB91 / qacE / aadA16 / dfrA27 / ARR-3 / aac(6')-Ib-cr - 1..57862 57862


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11615.30 Da        Isoelectric Point: 6.4672

>T265526 WP_013023785.1 NZ_CP113189:c6172-5867 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT265526 WP_001568025.1 NZ_CP113189:c6392-6174 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4ZZW6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References