Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 939638..940115 Replicon chromosome
Accession NC_017331
Organism Staphylococcus aureus subsp. aureus TW20

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag SATW20_RS04670 Protein ID WP_000052078.1
Coordinates 939638..939826 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SATW20_RS04675 Protein ID WP_001059690.1
Coordinates 939855..940115 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SATW20_RS04640 935678..936148 + 471 WP_000824472.1 hypothetical protein -
SATW20_RS04645 936489..937175 + 687 WP_001548082.1 thermonuclease family protein -
SATW20_RS04650 937532..937732 + 201 WP_001059082.1 cold-shock protein -
SATW20_RS04655 938229..938447 - 219 WP_000005886.1 hypothetical protein -
SATW20_RS04660 938509..938793 - 285 WP_001004395.1 hypothetical protein -
SATW20_RS04665 938881..939450 - 570 WP_001106654.1 hypothetical protein -
SATW20_RS04670 939638..939826 - 189 WP_000052078.1 hypothetical protein Toxin
SATW20_RS04675 939855..940115 - 261 WP_001059690.1 hypothetical protein Antitoxin
SATW20_RS04680 940456..940659 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SATW20_RS04685 940656..940892 - 237 WP_000368687.1 hypothetical protein -
SATW20_RS04690 941117..941698 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
SATW20_RS04695 941771..942388 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
SATW20_RS04700 942543..943037 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SATW20_RS04705 943436..943858 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SATW20_RS04710 944006..944722 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 934321..964383 30062


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T26552 WP_000052078.1 NC_017331:c939826-939638 [Staphylococcus aureus subsp. aureus TW20]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T26552 NC_017331:c939826-939638 [Staphylococcus aureus subsp. aureus TW20]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT26552 WP_001059690.1 NC_017331:c940115-939855 [Staphylococcus aureus subsp. aureus TW20]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT26552 NC_017331:c940115-939855 [Staphylococcus aureus subsp. aureus TW20]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References