265519

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 200234..200756 Replicon plasmid pSYCC2_tmex_279k
Accession NZ_CP113186
Organism Klebsiella pneumoniae strain SYCC2

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag OT482_RS01110 Protein ID WP_004181778.1
Coordinates 200472..200756 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag OT482_RS01105 Protein ID WP_004181777.1
Coordinates 200234..200482 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT482_RS01085 (OT482_01085) 195443..196264 - 822 WP_004181772.1 hypothetical protein -
OT482_RS01090 (OT482_01090) 196326..196679 - 354 WP_004181774.1 hypothetical protein -
OT482_RS01095 (OT482_01095) 196824..197810 - 987 WP_025368599.1 hypothetical protein -
OT482_RS01100 (OT482_01100) 198144..199943 - 1800 WP_004181776.1 ATP-dependent helicase -
OT482_RS01105 (OT482_01105) 200234..200482 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OT482_RS01110 (OT482_01110) 200472..200756 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT482_RS01115 (OT482_01115) 200773..200874 - 102 Protein_222 IS200/IS605 family transposase -
OT482_RS01120 (OT482_01120) 200910..202136 + 1227 WP_040209639.1 RNA-guided endonuclease TnpB family protein -
OT482_RS01125 (OT482_01125) 202407..202631 - 225 Protein_224 transposase -
OT482_RS01130 (OT482_01130) 202710..203138 - 429 WP_077257669.1 IS200/IS605 family transposase -
OT482_RS01135 (OT482_01135) 203174..204361 + 1188 WP_040209642.1 RNA-guided endonuclease TnpB family protein -
OT482_RS01140 (OT482_01140) 204406..204777 - 372 WP_040209644.1 hypothetical protein -
OT482_RS01145 (OT482_01145) 204774..205118 - 345 WP_223811496.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 - 1..279422 279422


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T265519 WP_004181778.1 NZ_CP113186:200472-200756 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT265519 WP_004181777.1 NZ_CP113186:200234-200482 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References