Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 36154..37064 | Replicon | plasmid pSYCC2_tmex_279k |
| Accession | NZ_CP113186 | ||
| Organism | Klebsiella pneumoniae strain SYCC2 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | OT482_RS00255 | Protein ID | WP_004181896.1 |
| Coordinates | 36594..37064 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | OT482_RS00250 | Protein ID | WP_004181895.1 |
| Coordinates | 36154..36597 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OT482_RS00225 (OT482_00225) | 31309..31524 | - | 216 | Protein_44 | IS200/IS605 family transposase | - |
| OT482_RS00230 (OT482_00230) | 31526..32095 | + | 570 | Protein_45 | transposase | - |
| OT482_RS00235 (OT482_00235) | 32787..34274 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| OT482_RS00240 (OT482_00240) | 34360..34782 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| OT482_RS00245 (OT482_00245) | 34782..36053 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| OT482_RS00250 (OT482_00250) | 36154..36597 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| OT482_RS00255 (OT482_00255) | 36594..37064 | + | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| OT482_RS00260 (OT482_00260) | 37174..37434 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| OT482_RS00265 (OT482_00265) | 38157..38315 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| OT482_RS00270 (OT482_00270) | 38918..39892 | + | 975 | WP_040222313.1 | hypothetical protein | - |
| OT482_RS00275 (OT482_00275) | 40090..40467 | - | 378 | WP_004181901.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 | - | 1..279422 | 279422 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T265518 WP_004181896.1 NZ_CP113186:36594-37064 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT265518 WP_004181895.1 NZ_CP113186:36154-36597 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |