265516

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 205299..205821 Replicon plasmid pSYCC1_tmex_287k
Accession NZ_CP113179
Organism Klebsiella pneumoniae strain SYCC1

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag OT490_RS26650 Protein ID WP_004181778.1
Coordinates 205537..205821 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag OT490_RS26645 Protein ID WP_004181777.1
Coordinates 205299..205547 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT490_RS26625 (OT490_26625) 200508..201329 - 822 WP_004181772.1 hypothetical protein -
OT490_RS26630 (OT490_26630) 201391..201744 - 354 WP_004181774.1 hypothetical protein -
OT490_RS26635 (OT490_26635) 201889..202875 - 987 WP_094965947.1 hypothetical protein -
OT490_RS26640 (OT490_26640) 203209..205008 - 1800 WP_267721726.1 ATP-dependent helicase -
OT490_RS26645 (OT490_26645) 205299..205547 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OT490_RS26650 (OT490_26650) 205537..205821 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT490_RS26655 (OT490_26655) 205838..205939 - 102 Protein_227 IS200/IS605 family transposase -
OT490_RS26660 (OT490_26660) 205975..207201 + 1227 WP_040209639.1 RNA-guided endonuclease TnpB family protein -
OT490_RS26665 (OT490_26665) 207472..207696 - 225 Protein_229 transposase -
OT490_RS26670 (OT490_26670) 207775..208203 - 429 WP_077257669.1 IS200/IS605 family transposase -
OT490_RS26675 (OT490_26675) 208239..209426 + 1188 WP_040209642.1 RNA-guided endonuclease TnpB family protein -
OT490_RS26680 (OT490_26680) 209471..209842 - 372 WP_040209644.1 hypothetical protein -
OT490_RS26685 (OT490_26685) 209839..210183 - 345 WP_223811496.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 / mcr-1.1 - 1..287882 287882


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T265516 WP_004181778.1 NZ_CP113179:205537-205821 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT265516 WP_004181777.1 NZ_CP113179:205299-205547 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References