Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 113689..114440 Replicon plasmid pSYCC1_tmex_287k
Accession NZ_CP113179
Organism Klebsiella pneumoniae strain SYCC1

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag OT490_RS26145 Protein ID WP_014386536.1
Coordinates 113689..114171 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag OT490_RS26150 Protein ID WP_004902250.1
Coordinates 114162..114440 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT490_RS26125 (OT490_26125) 110088..110735 - 648 WP_014386537.1 EcsC family protein -
OT490_RS26130 (OT490_26130) 110762..111517 - 756 WP_004902235.1 DUF2971 domain-containing protein -
OT490_RS26135 (OT490_26135) 111618..112010 - 393 WP_032442757.1 hypothetical protein -
OT490_RS26140 (OT490_26140) 112115..112654 - 540 WP_004902239.1 hypothetical protein -
OT490_RS26145 (OT490_26145) 113689..114171 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
OT490_RS26150 (OT490_26150) 114162..114440 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
OT490_RS26155 (OT490_26155) 114559..114771 - 213 WP_004902255.1 hypothetical protein -
OT490_RS26160 (OT490_26160) 114879..115220 - 342 WP_004902257.1 hypothetical protein -
OT490_RS26165 (OT490_26165) 116042..116500 - 459 WP_014386535.1 hypothetical protein -
OT490_RS26170 (OT490_26170) 117754..118638 + 885 WP_004186900.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 / mcr-1.1 - 1..287882 287882


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T265515 WP_014386536.1 NZ_CP113179:c114171-113689 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT265515 WP_004902250.1 NZ_CP113179:c114440-114162 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References