265509

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4626571..4627381 Replicon chromosome
Accession NZ_CP113178
Organism Klebsiella pneumoniae strain SYCC1

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag OT490_RS22345 Protein ID WP_004178461.1
Coordinates 4626571..4627104 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag OT490_RS22350 Protein ID WP_002887278.1
Coordinates 4627115..4627381 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT490_RS22340 (4625402) 4625402..4626523 + 1122 WP_002887282.1 cupin domain-containing protein -
OT490_RS22345 (4626571) 4626571..4627104 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
OT490_RS22350 (4627115) 4627115..4627381 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
OT490_RS22355 (4627484) 4627484..4628917 - 1434 WP_004178459.1 Cu(+)/Ag(+) sensor histidine kinase -
OT490_RS22360 (4628907) 4628907..4629590 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
OT490_RS22365 (4629762) 4629762..4631147 + 1386 WP_004178457.1 efflux transporter outer membrane subunit -
OT490_RS22370 (4631165) 4631165..4631509 + 345 WP_004197273.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T265509 WP_004178461.1 NZ_CP113178:c4627104-4626571 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT265509 WP_002887278.1 NZ_CP113178:c4627381-4627115 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLZ1

References