265506

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2712004..2713592 Replicon chromosome
Accession NZ_CP113178
Organism Klebsiella pneumoniae strain SYCC1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OT490_RS13230 Protein ID WP_004179815.1
Coordinates 2712004..2713326 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OT490_RS13235 Protein ID WP_004176198.1
Coordinates 2713326..2713592 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT490_RS13215 (2707060) 2707060..2709561 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
OT490_RS13220 (2709549) 2709549..2710553 + 1005 WP_004179822.1 fimbrial protein -
OT490_RS13225 (2710695) 2710695..2711987 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OT490_RS13230 (2712004) 2712004..2713326 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
OT490_RS13235 (2713326) 2713326..2713592 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OT490_RS13240 (2713858) 2713858..2714184 - 327 WP_002904788.1 hydroxyisourate hydrolase -
OT490_RS13245 (2714181) 2714181..2714681 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OT490_RS13250 (2714659) 2714659..2716038 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
OT490_RS13255 (2716384) 2716384..2717538 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OT490_RS13260 (2717519) 2717519..2718442 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T265506 WP_004179815.1 NZ_CP113178:c2713326-2712004 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT265506 WP_004176198.1 NZ_CP113178:c2713592-2713326 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References