265501

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 841602..842259 Replicon chromosome
Accession NZ_CP113178
Organism Klebsiella pneumoniae strain SYCC1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OT490_RS04155 Protein ID WP_002916310.1
Coordinates 841849..842259 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OT490_RS04150 Protein ID WP_002916312.1
Coordinates 841602..841868 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT490_RS04125 (836758) 836758..838191 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
OT490_RS04130 (838310) 838310..839038 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OT490_RS04135 (839088) 839088..839399 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
OT490_RS04140 (839563) 839563..840222 + 660 WP_002916317.1 hemolysin III family protein -
OT490_RS04145 (840373) 840373..841356 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
OT490_RS04150 (841602) 841602..841868 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OT490_RS04155 (841849) 841849..842259 + 411 WP_002916310.1 protein YgfX Toxin
OT490_RS04160 (842266) 842266..842787 - 522 WP_004144730.1 flavodoxin FldB -
OT490_RS04165 (842888) 842888..843784 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OT490_RS04170 (843807) 843807..844520 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OT490_RS04175 (844526) 844526..846259 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T265501 WP_002916310.1 NZ_CP113178:841849-842259 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT265501 WP_002916312.1 NZ_CP113178:841602-841868 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References