Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5239944..5240569 Replicon chromosome
Accession NZ_CP113173
Organism Klebsiella pneumoniae strain TSYCC10-2

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag OT486_RS25700 Protein ID WP_004187928.1
Coordinates 5239944..5240327 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OT486_RS25705 Protein ID WP_004150355.1
Coordinates 5240327..5240569 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT486_RS25685 (5237310) 5237310..5238212 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OT486_RS25690 (5238209) 5238209..5238844 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OT486_RS25695 (5238841) 5238841..5239770 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OT486_RS25700 (5239944) 5239944..5240327 - 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
OT486_RS25705 (5240327) 5240327..5240569 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OT486_RS25710 (5240763) 5240763..5241680 + 918 WP_032437488.1 alpha/beta hydrolase -
OT486_RS25715 (5241694) 5241694..5242635 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OT486_RS25720 (5242680) 5242680..5243117 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OT486_RS25725 (5243114) 5243114..5243974 - 861 WP_004146232.1 virulence factor BrkB family protein -
OT486_RS25730 (5243968) 5243968..5244567 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T265495 WP_004187928.1 NZ_CP113173:c5240327-5239944 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT265495 WP_004150355.1 NZ_CP113173:c5240569-5240327 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GDF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References