Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 895235..895892 Replicon chromosome
Accession NZ_CP113173
Organism Klebsiella pneumoniae strain TSYCC10-2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OT486_RS04550 Protein ID WP_002916310.1
Coordinates 895482..895892 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OT486_RS04545 Protein ID WP_002916312.1
Coordinates 895235..895501 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT486_RS04520 (890391) 890391..891824 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
OT486_RS04525 (891943) 891943..892671 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OT486_RS04530 (892721) 892721..893032 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OT486_RS04535 (893196) 893196..893855 + 660 WP_002916317.1 hemolysin III family protein -
OT486_RS04540 (894006) 894006..894989 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OT486_RS04545 (895235) 895235..895501 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OT486_RS04550 (895482) 895482..895892 + 411 WP_002916310.1 protein YgfX Toxin
OT486_RS04555 (895899) 895899..896420 - 522 WP_002916308.1 flavodoxin FldB -
OT486_RS04560 (896521) 896521..897417 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OT486_RS04565 (897440) 897440..898153 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OT486_RS04570 (898159) 898159..899892 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T265484 WP_002916310.1 NZ_CP113173:895482-895892 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT265484 WP_002916312.1 NZ_CP113173:895235-895501 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References