Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4838236..4839917 Replicon chromosome
Accession NZ_CP113168
Organism Klebsiella pneumoniae strain TSNTC34-1

Toxin (Protein)


Gene name mosT Uniprot ID A6TH06
Locus tag OT488_RS23555 Protein ID WP_015959269.1
Coordinates 4838236..4839111 (-) Length 292 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag OT488_RS23560 Protein ID WP_004177809.1
Coordinates 4839159..4839917 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT488_RS23535 (4833542) 4833542..4835062 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
OT488_RS23540 (4835059) 4835059..4836057 + 999 WP_002885172.1 ribose ABC transporter permease -
OT488_RS23545 (4836088) 4836088..4837029 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OT488_RS23550 (4837104) 4837104..4838111 + 1008 WP_015959270.1 carbohydrate kinase family protein -
OT488_RS23555 (4838236) 4838236..4839111 - 876 WP_015959269.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OT488_RS23560 (4839159) 4839159..4839917 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OT488_RS23565 (4840003) 4840003..4840731 - 729 WP_032413197.1 response regulator transcription factor -
OT488_RS23570 (4841004) 4841004..4843151 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
OT488_RS23575 (4843148) 4843148..4843291 - 144 WP_162897205.1 hypothetical protein -
OT488_RS23580 (4843729) 4843729..4844415 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(7-264)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 292 a.a.        Molecular weight: 32990.17 Da        Isoelectric Point: 5.4637

>T265477 WP_015959269.1 NZ_CP113168:c4839111-4838236 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 876 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT265477 WP_004177809.1 NZ_CP113168:c4839917-4839159 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6TH06

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References