Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4678497..4679013 Replicon chromosome
Accession NZ_CP113168
Organism Klebsiella pneumoniae strain TSNTC34-1

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag OT488_RS22740 Protein ID WP_009486548.1
Coordinates 4678497..4678781 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OT488_RS22745 Protein ID WP_002886901.1
Coordinates 4678771..4679013 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT488_RS22715 (4673914) 4673914..4674177 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
OT488_RS22720 (4674307) 4674307..4674480 + 174 WP_032433782.1 hypothetical protein -
OT488_RS22725 (4674483) 4674483..4675226 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OT488_RS22730 (4675583) 4675583..4677721 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OT488_RS22735 (4678029) 4678029..4678493 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OT488_RS22740 (4678497) 4678497..4678781 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT488_RS22745 (4678771) 4678771..4679013 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OT488_RS22750 (4679091) 4679091..4681001 - 1911 WP_009486549.1 PRD domain-containing protein -
OT488_RS22755 (4681024) 4681024..4682178 - 1155 WP_002886900.1 lactonase family protein -
OT488_RS22760 (4682245) 4682245..4682985 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T265476 WP_009486548.1 NZ_CP113168:c4678781-4678497 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT265476 WP_002886901.1 NZ_CP113168:c4679013-4678771 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References