Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 835747..836404 Replicon chromosome
Accession NZ_CP113168
Organism Klebsiella pneumoniae strain TSNTC34-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OT488_RS04190 Protein ID WP_002916310.1
Coordinates 835994..836404 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OT488_RS04185 Protein ID WP_002916312.1
Coordinates 835747..836013 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT488_RS04160 (830903) 830903..832336 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
OT488_RS04165 (832455) 832455..833183 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OT488_RS04170 (833233) 833233..833544 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
OT488_RS04175 (833708) 833708..834367 + 660 WP_002916317.1 hemolysin III family protein -
OT488_RS04180 (834518) 834518..835501 - 984 WP_267694184.1 tRNA-modifying protein YgfZ -
OT488_RS04185 (835747) 835747..836013 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OT488_RS04190 (835994) 835994..836404 + 411 WP_002916310.1 protein YgfX Toxin
OT488_RS04195 (836411) 836411..836932 - 522 WP_004144730.1 flavodoxin FldB -
OT488_RS04200 (837033) 837033..837929 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OT488_RS04205 (837952) 837952..838665 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OT488_RS04210 (838671) 838671..840404 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T265466 WP_002916310.1 NZ_CP113168:835994-836404 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT265466 WP_002916312.1 NZ_CP113168:835747-836013 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References