Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5321719..5323400 Replicon chromosome
Accession NZ_CP113165
Organism Klebsiella pneumoniae strain TSNTC10-1

Toxin (Protein)


Gene name mosT Uniprot ID A6TH06
Locus tag OT484_RS26450 Protein ID WP_015959269.1
Coordinates 5321719..5322594 (-) Length 292 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag OT484_RS26455 Protein ID WP_004177809.1
Coordinates 5322642..5323400 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT484_RS26430 (OT484_26430) 5317025..5318545 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
OT484_RS26435 (OT484_26435) 5318542..5319540 + 999 WP_002885172.1 ribose ABC transporter permease -
OT484_RS26440 (OT484_26440) 5319571..5320512 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OT484_RS26445 (OT484_26445) 5320587..5321594 + 1008 WP_015959270.1 carbohydrate kinase family protein -
OT484_RS26450 (OT484_26450) 5321719..5322594 - 876 WP_015959269.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OT484_RS26455 (OT484_26455) 5322642..5323400 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OT484_RS26460 (OT484_26460) 5323486..5324214 - 729 WP_032413197.1 response regulator transcription factor -
OT484_RS26465 (OT484_26465) 5324487..5326634 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
OT484_RS26470 (OT484_26470) 5326631..5326774 - 144 WP_162897205.1 hypothetical protein -
OT484_RS26475 (OT484_26475) 5327212..5327898 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(7-264)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 292 a.a.        Molecular weight: 32990.17 Da        Isoelectric Point: 5.4637

>T265459 WP_015959269.1 NZ_CP113165:c5322594-5321719 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 876 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT265459 WP_004177809.1 NZ_CP113165:c5323400-5322642 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6TH06

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References