Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5162777..5163293 Replicon chromosome
Accession NZ_CP113165
Organism Klebsiella pneumoniae strain TSNTC10-1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag OT484_RS25640 Protein ID WP_002886902.1
Coordinates 5162777..5163061 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OT484_RS25645 Protein ID WP_002886901.1
Coordinates 5163051..5163293 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT484_RS25615 (OT484_25615) 5158261..5158569 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
OT484_RS25620 (OT484_25620) 5158654..5158827 + 174 WP_002886906.1 hypothetical protein -
OT484_RS25625 (OT484_25625) 5158830..5159573 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OT484_RS25630 (OT484_25630) 5159930..5162068 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
OT484_RS25635 (OT484_25635) 5162309..5162773 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OT484_RS25640 (OT484_25640) 5162777..5163061 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT484_RS25645 (OT484_25645) 5163051..5163293 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OT484_RS25650 (OT484_25650) 5163371..5165281 - 1911 WP_004152270.1 PRD domain-containing protein -
OT484_RS25655 (OT484_25655) 5165304..5166458 - 1155 WP_002886900.1 lactonase family protein -
OT484_RS25660 (OT484_25660) 5166524..5167264 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T265458 WP_002886902.1 NZ_CP113165:c5163061-5162777 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT265458 WP_002886901.1 NZ_CP113165:c5163293-5163051 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References