Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3031012..3032600 Replicon chromosome
Accession NZ_CP113165
Organism Klebsiella pneumoniae strain TSNTC10-1

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag OT484_RS15075 Protein ID WP_002904792.1
Coordinates 3031012..3032334 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag OT484_RS15080 Protein ID WP_002904790.1
Coordinates 3032334..3032600 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT484_RS15060 (OT484_15060) 3026068..3028569 + 2502 WP_032433099.1 fimbria/pilus outer membrane usher protein -
OT484_RS15065 (OT484_15065) 3028557..3029561 + 1005 WP_032433097.1 fimbrial protein -
OT484_RS15070 (OT484_15070) 3029703..3030995 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OT484_RS15075 (OT484_15075) 3031012..3032334 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
OT484_RS15080 (OT484_15080) 3032334..3032600 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OT484_RS15085 (OT484_15085) 3032986..3033312 - 327 WP_002904788.1 hydroxyisourate hydrolase -
OT484_RS15090 (OT484_15090) 3033309..3033809 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OT484_RS15095 (OT484_15095) 3033787..3035166 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
OT484_RS15100 (OT484_15100) 3035512..3036666 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OT484_RS15105 (OT484_15105) 3036647..3037570 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T265455 WP_002904792.1 NZ_CP113165:c3032334-3031012 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT265455 WP_002904790.1 NZ_CP113165:c3032600-3032334 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References