Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1819493..1820229 Replicon chromosome
Accession NZ_CP113165
Organism Klebsiella pneumoniae strain TSNTC10-1

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag OT484_RS09030 Protein ID WP_032433360.1
Coordinates 1819747..1820229 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag OT484_RS09025 Protein ID WP_003026799.1
Coordinates 1819493..1819759 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT484_RS09000 (OT484_09000) 1815139..1816278 + 1140 WP_032433368.1 mannitol dehydrogenase -
OT484_RS09005 (OT484_09005) 1816307..1816969 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
OT484_RS09010 (OT484_09010) 1816953..1817957 + 1005 WP_032433364.1 dihydroxyacetone kinase subunit DhaK -
OT484_RS09015 (OT484_09015) 1817975..1818607 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
OT484_RS09020 (OT484_09020) 1818617..1819180 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
OT484_RS09025 (OT484_09025) 1819493..1819759 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
OT484_RS09030 (OT484_09030) 1819747..1820229 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
OT484_RS09035 (OT484_09035) 1821402..1822346 - 945 WP_077254249.1 fimbrial protein -
OT484_RS09040 (OT484_09040) 1822358..1822936 - 579 WP_032432061.1 type 1 fimbrial protein -
OT484_RS09045 (OT484_09045) 1822940..1823680 - 741 WP_050597964.1 molecular chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1788356..1831172 42816


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T265450 WP_032433360.1 NZ_CP113165:1819747-1820229 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT265450 WP_003026799.1 NZ_CP113165:1819493-1819759 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References