Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1802802..1803445 Replicon chromosome
Accession NZ_CP113165
Organism Klebsiella pneumoniae strain TSNTC10-1

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag OT484_RS08935 Protein ID WP_032433387.1
Coordinates 1803029..1803445 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag OT484_RS08930 Protein ID WP_001261276.1
Coordinates 1802802..1803032 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT484_RS08915 (OT484_08915) 1797824..1798911 + 1088 Protein_1720 transcriptional regulator -
OT484_RS08920 (OT484_08920) 1798914..1801154 + 2241 WP_045326788.1 P-loop NTPase fold protein -
OT484_RS08925 (OT484_08925) 1801682..1802497 - 816 WP_032433388.1 hypothetical protein -
OT484_RS08930 (OT484_08930) 1802802..1803032 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OT484_RS08935 (OT484_08935) 1803029..1803445 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
OT484_RS08940 (OT484_08940) 1803601..1804581 + 981 WP_032433385.1 hypothetical protein -
OT484_RS08945 (OT484_08945) 1804776..1806347 - 1572 WP_032433383.1 AAA family ATPase -
OT484_RS08950 (OT484_08950) 1806666..1806914 + 249 WP_032433382.1 hypothetical protein -
OT484_RS08955 (OT484_08955) 1806973..1807491 + 519 WP_045326794.1 hypothetical protein -
OT484_RS08960 (OT484_08960) 1807522..1808013 + 492 WP_032433378.1 hypothetical protein -
OT484_RS08965 (OT484_08965) 1808073..1808276 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1788356..1831172 42816


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T265449 WP_032433387.1 NZ_CP113165:1803029-1803445 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT265449 WP_001261276.1 NZ_CP113165:1802802-1803032 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References