Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 219848..220473 Replicon chromosome
Accession NZ_CP113165
Organism Klebsiella pneumoniae strain TSNTC10-1

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OT484_RS01045 Protein ID WP_002882817.1
Coordinates 219848..220231 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OT484_RS01050 Protein ID WP_004150355.1
Coordinates 220231..220473 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT484_RS01030 (OT484_01030) 217214..218116 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OT484_RS01035 (OT484_01035) 218113..218748 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OT484_RS01040 (OT484_01040) 218745..219674 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OT484_RS01045 (OT484_01045) 219848..220231 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OT484_RS01050 (OT484_01050) 220231..220473 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OT484_RS01055 (OT484_01055) 220678..221595 + 918 WP_021466676.1 alpha/beta hydrolase -
OT484_RS01060 (OT484_01060) 221609..222550 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OT484_RS01065 (OT484_01065) 222595..223032 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OT484_RS01070 (OT484_01070) 223029..223889 - 861 WP_004146232.1 virulence factor BrkB family protein -
OT484_RS01075 (OT484_01075) 223883..224482 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T265445 WP_002882817.1 NZ_CP113165:c220231-219848 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT265445 WP_004150355.1 NZ_CP113165:c220473-220231 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References