Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3419205..3419821 Replicon chromosome
Accession NZ_CP113163
Organism Citrobacter braakii strain LBA3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MKJ05_RS16295 Protein ID WP_016155182.1
Coordinates 3419205..3419579 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MKJ05_RS16300 Protein ID WP_181818053.1
Coordinates 3419579..3419821 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKJ05_RS16280 (MKJ05_16280) 3416708..3417610 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
MKJ05_RS16285 (MKJ05_16285) 3417607..3418242 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
MKJ05_RS16290 (MKJ05_16290) 3418239..3419168 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
MKJ05_RS16295 (MKJ05_16295) 3419205..3419579 - 375 WP_016155182.1 type II toxin-antitoxin system VapC family toxin Toxin
MKJ05_RS16300 (MKJ05_16300) 3419579..3419821 - 243 WP_181818053.1 CopG family transcriptional regulator Antitoxin
MKJ05_RS16305 (MKJ05_16305) 3420027..3420956 + 930 WP_267583561.1 alpha/beta hydrolase -
MKJ05_RS16310 (MKJ05_16310) 3421041..3421352 + 312 WP_114683723.1 type II toxin-antitoxin system HigB family toxin -
MKJ05_RS16315 (MKJ05_16315) 3421349..3421801 + 453 WP_114683722.1 helix-turn-helix domain-containing protein -
MKJ05_RS16320 (MKJ05_16320) 3421819..3422760 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
MKJ05_RS16325 (MKJ05_16325) 3422805..3423242 - 438 WP_003028671.1 D-aminoacyl-tRNA deacylase -
MKJ05_RS16330 (MKJ05_16330) 3423239..3424111 - 873 WP_114683721.1 virulence factor BrkB family protein -
MKJ05_RS16335 (MKJ05_16335) 3424105..3424704 - 600 WP_114683720.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13678.84 Da        Isoelectric Point: 8.5373

>T265440 WP_016155182.1 NZ_CP113163:c3419579-3419205 [Citrobacter braakii]
MVTGSALFDTNILIDLFSGRSEAKLAIETWPPQNAISLITWMELMVGAKKYHQESRTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTRDFAGISGVVTPYTL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9423.70 Da        Isoelectric Point: 4.3224

>AT265440 WP_181818053.1 NZ_CP113163:c3419821-3419579 [Citrobacter braakii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLDRQDQAETTISRALGLWQGCEEDGVDYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References