Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2318955..2319575 Replicon chromosome
Accession NZ_CP113163
Organism Citrobacter braakii strain LBA3

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MKJ05_RS11135 Protein ID WP_002892050.1
Coordinates 2319357..2319575 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag MKJ05_RS11130 Protein ID WP_003021733.1
Coordinates 2318955..2319329 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKJ05_RS11120 (MKJ05_11120) 2314102..2315295 + 1194 WP_114682035.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MKJ05_RS11125 (MKJ05_11125) 2315318..2318467 + 3150 WP_114682034.1 efflux RND transporter permease AcrB -
MKJ05_RS11130 (MKJ05_11130) 2318955..2319329 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
MKJ05_RS11135 (MKJ05_11135) 2319357..2319575 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MKJ05_RS11140 (MKJ05_11140) 2319756..2320307 + 552 WP_200110267.1 maltose O-acetyltransferase -
MKJ05_RS11145 (MKJ05_11145) 2320424..2320894 + 471 WP_114682032.1 YlaC family protein -
MKJ05_RS11150 (MKJ05_11150) 2320972..2321112 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
MKJ05_RS11155 (MKJ05_11155) 2321114..2321374 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
MKJ05_RS11160 (MKJ05_11160) 2321563..2323116 + 1554 WP_267589220.1 EAL domain-containing protein -
MKJ05_RS11165 (MKJ05_11165) 2323168..2323521 - 354 WP_114682030.1 DUF1428 family protein -
MKJ05_RS11170 (MKJ05_11170) 2323586..2324215 - 630 WP_200110266.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T265438 WP_002892050.1 NZ_CP113163:2319357-2319575 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT265438 WP_003021733.1 NZ_CP113163:2318955-2319329 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References